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. 2019 Apr 4;17:111. doi: 10.1186/s12967-019-1845-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — HUVECs incubation with BMSCs induced angiogenic factor expression and activated the TGFβ/Smad2/3 signalling pathway. a Western blot assay to determine the expression of HUVEC-derived TSP4, VEGF, Ang-1, MMP9, MMP2 and p-cdc42/Rac1 after incubation with BMSCs for the three groups (HUVEC, BMSC + HUVEC and TSP4-BMSC + HUVEC). b Representative western blot results of TSP4, VEGF, Ang-1, MMP9, MMP2 and p-cdc42/Rac1 and quantitative analysis at 48 h after co-incubation. Data are expressed as the mean ± SD. **p < 0.01, *p < 0.05. c Representative western blot results for p-Smad2/3 and TGFβ in HUVECs incubated with BMSCs in the four groups (HUVEC, BMSC + HUVEC, TSP4-BMSC + HUVEC and TSP4-BMSC + HUVEC + SIS3); d quantitative analysis is presented. Data are expressed as the mean ± SD. **p < 0.01, *p < 0.05