Table 1.
Odd ratios (ORs) and 95% CI of NIHL– associated SNPs
| Genotype | Control | NIHL | P-valuea | OR (95% CI)a |
|---|---|---|---|---|
| Pcdh15/rs11004085 | ||||
| TT | 346 | 382 | 0.015 | 1 |
| CT | 120 | 88 | 0.005 | 0.59 (0.41, 0.85) |
| CC | 5 | 3 | 0.395 | 0.53 (0.12, 2.31) |
| Ptrend | 0.005 | |||
| CT/CC | 125 | 91 | 0.004 | 0.59 (0.41, 0.84) |
| EYA4/ rs3777781 | ||||
| TT | 137 | 166 | 0.045 | 1 |
| AT | 236 | 235 | 0.116 | 0.76 (0.54, 1.07) |
| AA | 96 | 71 | 0.015 | 0.57 (0.36, 0.90) |
| Ptrend | 0.016 | |||
| AT/AA | 332 | 306 | 0.047 | 0.72 (0.52, 0.99) |
| EYA4/ rs212769 | ||||
| GG | 354 | 336 | 0.094 | 1 |
| AG | 112 | 129 | 0.062 | 1.40 (0.98, 1.98) |
| AA | 5 | 8 | 0.214 | 2.37 (0.61, 9.23) |
| Ptrend | 0.033 | |||
| AG/AA | 117 | 137 | 0.041 | 1.43 (1.01, 2.02) |
| MYO1A/rs1552245 | ||||
| GG | 293 | 308 | 0.088 | 1 |
| AG | 164 | 156 | 0.032 | 0.70 (0.51, 0.97) |
| AA | 14 | 8 | 0.448 | 0.68 (0.25, 1.84) |
| Ptrend | 0.032 | |||
| AG/AA | 178 | 164 | 0.027 | 0.70 (0.51, 0.96) |
| DFNA5/ rs2521768 | ||||
| TT | 289 | 305 | 0.158 | 1 |
| CT | 155 | 148 | 0.249 | 0.82 (0.60, 1.14) |
| CC | 27 | 19 | 0.089 | 0.52 (0.25, 1.10) |
| Ptrend | 0.064 | |||
| CT/CC | 182 | 167 | 0.122 | 0.78 (0.57, 1.07) |
| CDH23/rs2394795 | ||||
| CC | 134 | 108 | 0.122 | 1 |
| TC | 240 | 244 | 0.081 | 1.39 (0.96, 2.02) |
| TT | 97 | 120 | 0.06 | 1.53 (0.98, 2.38) |
| Ptrend | 0.058 | |||
| TC/TT | 337 | 364 | 0.043 | 1.44 (1.01, 2.05) |
| CDH23/rs4747192 | ||||
| CC | 168 | 193 | 0.213 | 1 |
| TC | 230 | 220 | 0.113 | 0.77 (0.55, 1.06) |
| TT | 73 | 60 | 0.189 | 0.73 (0.45, 1.17) |
| Ptrend | 0.106 | |||
| TC/TT | 303 | 280 | 0.084 | 0.76 (0.56, 1.04) |
| MYO7A/ rs1043421 | ||||
| TT | 252 | 282 | 0.16 | 1 |
| AT | 192 | 170 | 0.066 | 0.74 (0.54, 1.02) |
| AA | 28 | 21 | 0.384 | 0.73 (0.37, 1.47) |
| Ptrend | 0.071 | |||
| AT/AA | 220 | 191 | 0.057 | 0.74 (0.55, 1.01) |
| KCNMA1/rs696211 | ||||
| TT | 247 | 247 | 0.052 | 1 |
| CT | 178 | 194 | 0.904 | 0.98 (0.71, 1.35) |
| CC | 45 | 31 | 0.016 | 0.47 (0.26, 0.87) |
| Ptrend | 0.080 | |||
| TT + CT | 425 | 441 | 0.016 | 0.48 (0.26, 0.87) |
| KCNMA1/ rs7910544 | ||||
| GG | 343 | 345 | 0.175 | 1 |
| CG | 121 | 111 | 0.652 | 0.92(0.65, 1.31) |
| CC | 7 | 16 | 0.077 | 2.70(0.90, 8.11) |
| Ptrend | 0.576 | |||
| GG + CG | 7 | 16 | 0.070 | 2.76(0.92,8.26) |
| CX43/rs3751385 | ||||
| CC | 131 | 109 | 0.134 | 1 |
| CT | 259 | 265 | 0.071 | 1.40 (0.97, 2.01) |
| TT | 80 | 99 | 0.086 | 1.50 (0.94, 2.39) |
| Ptrend | 0.081 | |||
| CT/TT | 339 | 364 | 0.056 | 1.41 (0.99, 1.99) |
| GRHL2/ rs471757 | ||||
| CC | 158 | 167 | 0.161 | 1 |
| CT | 208 | 217 | 0.889 | 0.98 (0.69, 1.37) |
| TT | 105 | 89 | 0.078 | 0.68 (0.45, 1.04) |
| Ptrend | 0.104 | |||
| CC + CT | 366 | 384 | 0.062 | 0.70 (0.48, 1.02) |
| GRHL2/ rs666026 | ||||
| TT | 244 | 222 | 0.147 | 1 |
| GT | 186 | 204 | 0.118 | 1.29 (0.94, 1.77) |
| GG | 40 | 46 | 0.121 | 1.55 (0.89, 2.71) |
| Ptrend | 0.051 | |||
| GT/GG | 226 | 250 | 0.065 | 1.33 (0.98, 1.80) |
| OTOG/ rs7106021 | ||||
| GG | 340 | 326 | 0.031 | 1 |
| GA | 116 | 136 | 0.014 | 1.55(1.09, 2.20) |
| AA | 14 | 10 | 0.485 | 0.72(0.29, 1.81) |
| Ptrend | 0.123 | |||
| GA + AA | 130 | 146 | 0.036 | 1.43(1.02, 2.00) |
a calculated with logistic regression adjusted by age, CNE, smoking, and drinking