Table 3.
Odd ratios (ORs) and 95% CI of NIHL– associated SNPs in the cohort study
| Genotype or GRS | N | NIHL | P | OR (95% CI) | |
|---|---|---|---|---|---|
| n | % | ||||
| EYA4/ rs212769 | |||||
| GG | 440 | 36 | 8.18 | 1 | |
| AG | 125 | 13 | 10.4 | 0.976 | 1.01(0.52, 2.19) |
| AA | 11 | 4 | 36.36 | 0.001 | 28.27(4.21, 189.85) |
| AA vs GG/AG | 11/565 | 4/49 | 36.36/8.67 | 0.005 | 6.710(1.77, 25.41) |
| KCNMA1/ rs7910544 | |||||
| GG | 424 | 46 | 10.85 | 1 | |
| CG | 143 | 5 | 3.5 | 0.017 | 0.31(0.12, 0.81) |
| CC | 9 | 2 | 22.22 | 0.157 | 3.72(0.60, 23.03) |
| CC vs CG/GG | 9/567 | 2/51 | 22.22/8.99 | 0.027 | 5.23(1.20, 22.71) |
| GRSa | |||||
| < 7 | 46 | 2 | 4.35 | 1 | |
| 7 | 75 | 4 | 5.33 | 0.537 | 1.74(0.30, 10.18) |
| 8 | 105 | 7 | 6.67 | 0.425 | 1.97(0.37, 10.49) |
| 9 | 129 | 15 | 11.63 | 0.084 | 3.99(0.83, 19.12) |
| ≥10 | 211 | 22 | 10.43 | 0.163 | 2.92(0.65, 13.16) |
| P trend | 0.092 | ||||
| < 9 | 226 | 13 | 5.75 | 1 | |
| ≥9 | 340 | 37 | 10.88 | 0.038 | 2.00(1.04,3.86) |
a GRS genetic risk score, was calculated as the sum of the risk allele in 14 NIHL-associated SNPs