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. 2019 Apr 5;18:80. doi: 10.1186/s12943-019-1015-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Schematic representation of the proposed mechanism of circDLST in GC cells. circDLST acted as a sponge of miR-502-5p to activate the NRAS/MEK1/ERK1/2 signaling and upregulate PCNA and MMP2 expression, leading to the tumorigenesis and metastasis of GC