Table 4.
Diagnostic Performance of US Characteristics for the Prediction of Malignancy in Thyroid Nodules with Echogenic foci Types with TIRADS Combination (High suspicion)
| Echogenic foci | TIRADS | Total | Benign | Malignant | Diagnostic Performance | ||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Accuracy | PPV | NPV | |||||
| Type 1 | + Web-based TIRADS (≥ 8) | 148 | 14 | 134 | 52.8 | 89.7 | 65.6 | 90.5 | 50.4 |
| + K-TIRADS High Suspicion | 156 | 19 | 137 | 53.9 | 86.0 | 65.1 | 87.8 | 50.0 | |
| + ATA High Suspicion | 163 | 21 | 142 | 66.7 | 69.6 | 67.4 | 87.1 | 40.3 | |
| + Russ et al. (≥ 4B) | 189 | 41 | 148 | 58.3 | 69.9 | 62.3 | 78.3 | 47.3 | |
| Type 2 | + Web-based TIRADS (≥ 8) | 37 | 3 | 34 | 22.2 | 94.4 | 41.1 | 91.9 | 30.0 |
| +K-TIRADS High Suspicion | 40 | 6 | 34 | 22.2 | 88.9 | 39.6 | 85.0 | 28.7 | |
| + ATA High Suspicion | 46 | 7 | 39 | 27.1 | 75.9 | 35.3 | 84.8 | 17.3 | |
| + Russ et al. (≥ 4B) | 47 | 8 | 39 | 25.5 | 85.2 | 41.1 | 83.0 | 28.8 | |
| Type 3 | + Web-based TIRADS (≥ 8) | 22 | 2 | 20 | 7.9 | 98.5 | 39.5 | 90.9 | 36.4 |
| +K-TIRADS High Suspicion | 37 | 6 | 31 | 12.2 | 95.6 | 41.3 | 83.8 | 36.8 | |
| + ATA High Suspicion | 38 | 6 | 32 | 15.0 | 91.3 | 33.7 | 84.2 | 25.8 | |
| + Russ et al. (≥ 4B) | 49 | 13 | 36 | 14.2 | 90.4 | 40.8 | 73.5 | 36.1 | |
| Type 4 | + Web-based TIRADS (≥ 8) | 2 | 1 | 1 | 0.4 | 99.3 | 34.9 | 50.0 | 34.8 |
| +K-TIRADS High Suspicion | 4 | 1 | 3 | 1.2 | 99.3 | 35.4 | 75.0 | 35.0 | |
| + ATA High Suspicion | 4 | 1 | 3 | 1.4 | 98.6 | 25.2 | 75.0 | 24.5 | |
| + Russ et al. (≥ 4B) | 6 | 2 | 4 | 1.6 | 98.5 | 35.4 | 66.7 | 34.9 | |
| Type 5 | + Web-based TIRADS (≥ 8) | 6 | 2 | 4 | 1.6 | 98.5 | 35.4 | 66.7 | 34.9 |
| +K-TIRADS High Suspicion | 5 | 1 | 4 | 1.6 | 99.3 | 35.6 | 80.0 | 35.1 | |
| + ATA High Suspicion | 5 | 1 | 4 | 1.9 | 98.6 | 25.5 | 80.0 | 24.5 | |
| + Russ et al. (≥ 4B) | 6 | 2 | 4 | 1.6 | 98.5 | 35.4 | 66.7 | 34.9 | |
| Type 6 | + Web-based TIRADS (≥ 8) | 21 | 2 | 19 | 7.5 | 98.5 | 39.2 | 90.5 | 36.3 |
| +K-TIRADS High Suspicion | 24 | 1 | 23 | 9.1 | 99.3 | 40.5 | 95.8 | 36.9 | |
| + ATA High Suspicion | 25 | 1 | 24 | 11.3 | 98.6 | 32.6 | 96.0 | 26.5 | |
| + Russ et al. (≥ 4B) | 28 | 3 | 25 | 9.8 | 97.8 | 40.5 | 89.3 | 36.7 | |
TIRADS thyroid image reporting and data system, ATA american thyroid association, PPV positive predictive value, NPV negative predictive value
Type 1 = Punctate echogenic foci (≤ 1 mm) with or without posterior shadowing
Type 2 = Punctate echogenic foci with comet-tail artifact
Type 3 = Large echogenic foci (> 1 mm) without shadowing
Type 4 = Macrocalcification (defined as large echogenic foci (> 1 mm) with shadowing)
Type 5 = Peripheral curvilinear or eggshell echogenic foci with or without shadowing
Type 6 = Nodules with more than one type of echogenic foci