Table 5.
Diagnostic Performance of US Characteristics for the Prediction of Malignancy in Thyroid Nodules with Echogenic foci Types with TIRADS Combination (Low suspicion)
| Echogenic foci | TIRADS | Total | Benign | Malignant | Diagnostic Performance | ||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Accuracy | PPV | NPV | |||||
| Type 1 | + Web-based TIRADS (< 8) | 59 | 40 | 19 | 7.5 | 70.6 | 29.5 | 32.2 | 29.0 |
| + K-TIRADSa | 51 | 35 | 16 | 6.3 | 74.3 | 30.0 | 31.4 | 29.8 | |
| + ATAa | 10 | 8 | 2 | 0.9 | 88.4 | 22.3 | 20.0 | 22.4 | |
| + Russ et al. (< 4B) | 18 | 13 | 5 | 2.0 | 90.4 | 32.8 | 27.8 | 33.1 | |
| Type 2 | + Web-based TIRADS (< 8) | 17 | 9 | 8 | 5.2 | 83.3 | 27.1 | 47.1 | 23.7 |
| + K-TIRADSa | 14 | 6 | 8 | 5.2 | 88.9 | 25.6 | 57.1 | 24.9 | |
| + ATAa | 3 | 2 | 1 | 0.7 | 93.1 | 16.2 | 33.3 | 15.9 | |
| + Russ et al. (<4B) | 7 | 4 | 3 | 2.0 | 92.6 | 25.6 | 42.9 | 25.0 | |
| Type 3 | + Web-based TIRADS (< 8) | 72 | 39 | 33 | 13.0 | 71.3 | 33.3 | 45.8 | 30.5 |
| + K-TIRADSa | 57 | 35 | 22 | 8.7 | 74.3 | 31.5 | 38.6 | 30.3 | |
| + ATAa | 19 | 17 | 2 | 0.9 | 75.4 | 19.1 | 10.5 | 19.8 | |
| + Russ et al. (<4B) | 45 | 28 | 17 | 6.7 | 79.4 | 32.1 | 37.8 | 31.3 | |
| Type 4 | + Web-based TIRADS (< 8) | 25 | 15 | 10 | 3.9 | 89.0 | 33.6 | 40.0 | 33.2 |
| + K-TIRADSa | 23 | 15 | 8 | 3.1 | 89.0 | 33.1 | 34.8 | 33.0 | |
| + ATAa | 6 | 5 | 1 | 0.5 | 92.8 | 23.0 | 16.7 | 23.2 | |
| + Russ et al. (<4B) | 21 | 14 | 7 | 2.8 | 89.7 | 33.1 | 33.3 | 33.1 | |
| Type 5 | + Web-based TIRADS (< 8) | 15 | 12 | 3 | 1.2 | 91.2 | 32.6 | 20.0 | 33.1 |
| + K-TIRADSa | 16 | 13 | 3 | 1.2 | 90.4 | 32.3 | 18.8 | 32.9 | |
| + ATAa | 6 | 5 | 1 | 0.5 | 92.8 | 23.0 | 16.7 | 23.2 | |
| + Russ et al. (<4B) | 15 | 12 | 3 | 1.2 | 91.2 | 32.6 | 20.0 | 33.1 | |
| Type 6 | + Web-based TIRADS (< 8) | 20 | 9 | 11 | 4.3 | 93.4 | 35.4 | 55.0 | 34.3 |
| + K-TIRADSa | 17 | 10 | 7 | 2.8 | 92.6 | 34.1 | 41.2 | 33.8 | |
| + ATAa | 6 | 4 | 2 | 0.9 | 94.2 | 23.8 | 33.3 | 23.6 | |
| + Russ et al. (< 4B) | 13 | 8 | 5 | 2.0 | 94.1 | 34.1 | 38.5 | 34.0 | |
TIRADS thyroid image reporting and data system, ATA american thyroid association, PPV positive predictive value, NPV negative predictive value
aOther than High suspicion category
Type 1 = Punctate echogenic foci (≤ 1 mm) with or without posterior shadowing
Type 2 = Punctate echogenic foci with comet-tail artifact
Type 3 = Large echogenic foci (> 1 mm) without shadowing
Type 4 = Macrocalcification (defined as large echogenic foci (> 1 mm) with shadowing
Type 5 = Peripheral curvilinear or eggshell echogenic foci with or without shadowing
Type 6 = Nodules with more than one type of echogenic foci