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. 2019 Apr 4;11:58. doi: 10.1186/s13148-019-0652-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Enrichment of dcSSc differentially methylated CpGs in regions overlapping histone modifications in the Roadmap Epigenomics Project data. Statistically significant enrichment outside the 99.9th percentile (−log₁₀ binomial p value ≥ 3.38) is colored red on the vertical axis. Panel shows marked enrichment for a histone modification representative of enhancers (H3K4me1) in blood cells (monocytes, hematopoietic stem cells, natural killer cells), fetal tissues (lung fibroblasts, large intestine, small intestine, adrenal gland, muscle leg, thymus), psoas muscle, and skin fibroblasts. Enrichment for a histone modification representative of polycomb-repressed regions (H3K27me3) was seen in hematopoietic stem cells