Table 1.

Genetic pleiotropy and enrichment of functional deleteriousness among genetic loci associated with childhood BMI and adult cardiometabolic traits

Adult cardiometabolic trait	Genetic pleiotropy			Functional annotation enrichment
	π11 (s.e.)	Pleiotropy test statistics	P value	π11 (s.e.)	Annotation test statistics	P value
Body mass index	0.055 (0.001)	23,690.45	< 10− 300	1.30 (0.04)	173.01	2.85 × 10−37
Coronary artery disease	0.01 (0)	1215.77	2.29 × 10−266	1.60 (0.13)	87.27	8.47 × 10−19
Fasting glucose	0 (0.001)	1.21	0.27	0.04 (2.74)	6.44	0.09
Fasting insulin	0.047 (0.003)	509.74	7.24 × 10−113	1.004 (0.22)	41.46	5.23 × 10−09
Hemoglobin A1c	0.006 (0)	87.12	1.02 × 10−20	2.52 (0.22)	48.73	1.49 × 10−10
HDL cholesterol	0.005 (0)	2151.79	< 10−300	1.54 (0.12)	88.39	4.86 × 10−19
Insulin secretion	0 (0)	0.89	0.35	7.31 (1.79)	38.69	2.01 × 10−08
Insulin sensitivity	0.013 (0.001)	393.57	1.38 × 10−87	1.54 (0.21)	45.63	6.81 × 10−10
LDL cholesterol	0.003 (0)	739.01	9.85 × 10−163	1.29 (0.20)	98.53	3.22 × 10−21
Myocardial infarction	0.01 (0)	887.48	5.16 × 10−195	1.68 (0.14)	58.51	1.22 × 10−12
Type 2 diabetes	0.007 (0)	855.26	5.23 × 10−188	1.37 (0.19)	65.95	3.14 × 10−14
Total cholesterol	0.005 (0)	1186.54	5.14 × 10−260	1.45 (0.15)	124.99	6.47 × 10−27
Triglycerides	0.003 (0)	1005.09	1.40 × 10−220	1.44 (0.17)	74.82	3.97 × 10−16
Waist circumference	0.026 (0)	14,809.27	< 10−300	1.43 (0.06)	112.69	2.89 × 10−24
Waist-to-hip ratio	0.019 (0)	5271.53	< 10− 300	1.60 (0.08)	113.88	1.61 × 10−24

π₁₁ is the probability of association of SNPs with both tested traits. q₁₁/q₀₀ is the ratio of the probability of jointly associated SNPs being functionally annotated to the probability of a null SNP (associated with neither trait) being functionally annotated