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. 2019 Apr 4;18:66. doi: 10.1186/s12934-019-1115-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Enhanced resistance to CVB3-induced acute myocarditis by oral immunization with VP1 IBs. Myocarditis severity was determined 7 days post-viral infection. a Body weight loss. b Cardiac function was detected by echocardiography using a 2-dimensional guided M-mode ultrasound system for each group. c Representative myocardial histopathological observation. d Myocardial histopathological scores. e The survival rate of mice was observed for 28 days following a lethal dose of CVB3 infection. **P < 0.01