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. 2019 Apr 5;16:73. doi: 10.1186/s12974-019-1462-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Confocal microscopy image of paranodes and box plots illustrating morphometric data and complement deposition of the acute patient. Paranodal immunofluorescence staining with anti-Caspr is reduced at paranodes of rats injected with IgG of the acute patient (a, lower image) compared to paranodes of a control rat (a, upper image). Scale bar = 10 μm. Complement deposition at the paranodes can be detected by immunofluorescence staining with anti-C1q (b). Morphometric analysis revealed a reduction of sum intensity (c), length of the nodal complex (d) and paranodal volume (e) in rats injected with IgG of the acute patient compared to control rats. (*0.1 > p > 0.01, **0.01 > p > 0.001, ***0.001 > p)