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. 2019 Jan 11;25(3):326–343. doi: 10.1093/humupd/dmy046

Figure 1.

Figure 1

The major structure of kisspeptins in humans, the peptides encoded by the KISS1 gene. All kisspeptins are the products generated by the cleavage of a common precursor named prepro-kisspeptin. The prepro-kisspeptin is a 145-amino acid peptide, which is further cleaved into the following four peptides with lower molecular weights: KP-54, KP-14, KP-13 and KP-10. All kisspeptins contain the RF-amide motif that can bind and activate KISS1R. This figure is modified from Pinilla et al. (2012); Hu et al. (2017).