Table I.
Expression of KISS1 and KISS1R at the utero-placental interface during mammalian pregnancy.
| Species | Cells or tissues reported | Trends across pregnancy | References |
|---|---|---|---|
| KISS1 | |||
| Human | vST, vCT, Decidua | Decreased in RSA compared with abortion | Wu et al. (2014) |
| Human | vST, vCT | Decreased in RSA compared with abortion | Park et al. (2012) |
| Human | vST; PB and DP (−) | Not investigated | Matjila et al. (2013) |
| Human | vCT | Not different between term pregnancy and early pregnancy | Janneau et al. (2002) |
| Human | Placenta (early and term pregnancy, PE) | Early pregnancy > Term pregnancy > PE | Cartwright and Williams (2012) |
| Human | Placenta (term pregnancy, PE); PB and DP (minimal) | Term pregnancy < PE | Matjila et al. (2016) |
| Human | Placenta (term pregnancy) | Circadian rhythm (two surges, 04:00 h and 12:00 h, respectively). | de Pedro et al. (2015) |
| Human | vST | Not investigated | Horikoshi et al. (2003) |
| Rat | Trophoblast giant cells | Gradually decreased | Terao et al. (2004) |
| Human | vST, vCT; EVTs (−) | First trimester > term pregnancy | Bilban et al. (2004) |
| Rat | Trophoblast giant cells (gestation Day 16 and Day 22) | Day 22 > Day 16 | Mark et al. (2013) |
| Human | Placenta | Preterm pregnancy > term pregnancy | Torricelli et al. (2008) |
| Cat | Luminal epithelial cells and uterine glands, stroma cells | Not investigated | Tanyapanyachon et al. (2018) |
| Dog | Superficial uterine glands, Syncytiotrophoblast | Not changed between pre-implantation and post-implantation | Schafer-Somi et al. (2017) |
| Mouse | Decidualizing stromal cells | Increased dynamically from D5 onward | Zhang et al. (2014) |
| Human | Endometrium | Glandular endometrium: ectopic > eutopic | Kolioulis et al. (2017) |
| Human | Epithelial cells (weak expression levels). ESCs (−) | Proliferative stage and early secretory phase | Baba et al. (2015) |
| ESCs (prominent expression levels) | Late secretory phase | ||
| Human | Endometrium | Glandular endometrium: Ectopic >eutopic, Stromal endometrium: no difference | Timologou et al. (2016) |
| Human | Luminal and glandular epithelial cells, stroma cells (−) | Not investigated | Cejudo Roman et al. (2012) |
| KISS1R | |||
| Human | vST, vCT | Decreased in RSA compared with abortion | Wu et al. (2014) |
| Deciduas | Not different between abortion and RSA | ||
| Human | vST, vCT | Not different between abortion and RSA | Park et al. (2012) |
| Human | vST, vCT, EVTs; PB and decidua basalis (−) | Not investigated | Matjila et al. (2013) |
| Human | vCT (early pregnancy) | First trimester > term pregnancy | Janneau et al. (2002) |
| Human | Placenta (early and term pregnancy, PE) | Early pregnancy > PE > term pregnancy | Cartwright and Williams (2012) |
| Human | Placenta, PB and DP (term pregnancy, PE) | Not different between term pregnancy and PE | Matjila et al. (2016) |
| Rat | Trophoblast giant cells | Low expression level | Terao et al. (2004) |
| Human | vST, vCT, EVTs | First trimester > term pregnancy | Bilban et al. (2004) |
| Rat | Placenta (gestation Day 16 and Day 22) | Day 22 > Day 16 | Mark et al. (2013) |
| Human | Umbilical vein endothelial cells | Not investigated | Ramaesh et al. (2010) |
| Mouse | Decidualizing stromal cells | Increased from D5 onward | Zhang et al. (2014) |
| Cat | Luminal epithelial cells and uterine glands. ESCs (−) | Not investigated | Tanyapanyachon et al. (2018) |
| Dog | Superficial and deep uterine glands | Higher in pre-implantation than post-implantation | Schafer-Somi et al. (2017) |
| Dog | Syncytiotrophoblast cells | Higher in mid-gestation than post-implantation | Schafer-Somi et al. (2017) |
| Human | Epithelial cells. ESCs (−) | Week expression levels | Baba et al. (2015) |
| Human | Luminal and glandular epithelial cells. ESCs (−) | Not investigated | Cejudo Roman et al. (2012) |
Abbreviations: RSA, recurrent spontaneous abortion; vST, villous syncytiotrophoblasts; vCT, villous cytotrophoblasts; EVTs, extravillous trophoblast cells; ESCs, endometrial stroma cells; DP, decidua parietalis; PB, placental bed.