Table III.
Summary of the effect of Kiss1/Kiss1r in genetically modified or mutant models (placental specific knockout or overall knockout) on fertility or placental function.
| Knockout model | Species | Fertility or placental function | References |
|---|---|---|---|
| Kiss1+/− or Kiss1−/−; Kiss1r+/− or Kiss1r−/− (fetus) | Mouse | Normal weight of fetus and placenta, normal nutrient transfer function of placenta at E15.5 days | Herreboudt et al. (2015) |
| Kiss1+/− or Kiss1r+/− (maternal) | Mouse | Fertile | Herreboudt et al. (2015) |
| Kiss1−/− (maternal) | Mouse | Fail to implant and infertile | Calder et al. (2014) |
| Kiss1r−/− (maternal) | Mouse | Infertile | Funes et al. (2003) |
| Kiss1r+/− (maternal) | Mouse | Fertile | Seminara et al. (2003) |
| Kiss1r−/− (maternal) | Mouse | Infertile | Seminara et al. (2003) |
| Kiss1r+/− (maternal) | Mouse | Fertile before 48-week-old Infertile at 48-week-old |
Gaytan et al. (2014) |
| Kiss1+/− (maternal) | Mouse | Fertile | Chan et al. (2011) |
| Kiss1+/− or Kiss1r+/− (maternal) | Mouse | Fertile | Lapatto et al. (2007) |
| Kiss1−/− or Kiss1r−/− (maternal) | Mouse | Infertile | Lapatto et al. (2007) |
| Kiss1−/− or Kiss1r−/− (maternal) | Mouse | Uterine growth suppressed and adenogenesis nearly stopped | Leon et al. (2016) |
| KISS1R+/− (maternal), KISS1R−/− (maternal) and KISS1R−/− (fetus) | Human | Fertile | Pallais et al. (2006) |
| KISS1+/− (maternal) and KISS1−/− (fetus) | Human | Fertile | Topaloglu et al. (2012) |