Table 2.
Clinical and biochemical characteristics of lean and obese men
| Controls (n = 16) | Obese (n = 8) | Obese + diabetes mellitus type 2 (n = 23) | p value | |
|---|---|---|---|---|
| Characteristics | ||||
| Age, years | 52 (14) | 40 (13) | 54 (11) | 0.027 |
| Weight, kg | 73 (13) | 141 (30) | 144 (20) | 0.0001 |
| BMI, kg/m2 | 23 (3) | 41 (7) | 46 (6) | 0.0001 |
| Fat mass,% | 24 (3) | 37 (6) | 44 (6) | 0.0001 |
| Plasma glucose, mg/dl | 0.82 (0.15) | 0.92 (0.06) | 1.48 (0.52) | 0.0001 |
| Plasma insulin, IU/l | 5 (3–6.8) | 25 (15–28) | 35 (23–47) | 0.0001 |
| CRP, mg/dl | 1.6 (1.2–2.1) | 3.9 (1.5–6.5) | 2.6 (2.1–4.1) | 0.012 |
| Fasting serum triglycerides, mg/dl | 101 (80–154) | 133 (90–285) | 148 (105–173) | 0.25 |
| MtDNA content | ||||
| Visceral adipose tissue | 0.80 (0.53–1.06) | 1.21 (0.96–1.39) | 1.24 (0.88–1.78) | 0.013 |
| Subcutaneous adipose tissue | 1.06 (0.79–1.16) | 1.35 (0.93–1.44) | 0.98 (0.88–1.77) | 0.24 |
| Adipocyte size, βm2 | ||||
| Visceral adipocyte size | 4,584 (2,127) | 8,558 (2,648) | 8,143 (2,281) | 0.0001 |
| Subcutaneous adipocyte size | 4,484 (1,615) | 8,642 (1,761) | 9,829 (1,355) | 0.0001 |
Data are presented as mean ± SD, or median (first, third quartile) in case of non-Gaussian distribution.