FIG 6.

Fusion inhibitory peptides protect from lethal infection with virus bearing the L454W F in vivo. SLAM suckling mice were infected intranasally with 5,000 PFU of MeV IC323-EGFP-F L454W. A subset of animals infected with 5,000 PFU (n = 9) was treated with HRC4 peptide intranasally (6 mg/kg) the day before and 4 h after infection (as we have previously done for wt virus [33]). The mock-infected group received vehicle at the same time (n = 11). The Mantel-Cox test was used for the survival comparison analysis. ***, P = 0.0007.