Table 4.
Summary of marker combinations for identifying mononuclear phagocytic cells across species (humans, mice, cattle, and pigs) based on phenotypic and transcriptomic data.
| Blood Monocytes (2, 8, 32, 39, 43, 49, 54–56) | cDC (5, 8, 16, 17, 39, 43, 44, 51, 54, 57–59) | ALDC * (9, 15, 19–21, 32, 48, 60, 61) | ALMacs * (15, 60) | MoDC (1, 3–8, 12–14, 16, 18, 34, 37, 38, 42–44, 54, 61, 62) | MoMacs (5, 6, 10–12, 16, 18, 34–37, 39, 43, 49, 51, 52, 58, 63) | Lung Macs (26, 63–65) | |
|---|---|---|---|---|---|---|---|
| MHCII | + | ++ | ++ | + | ++ | + | + |
| CD11c | + | + | + | + | + | + | + |
| CD1b | – | + | + | + | + | + | + |
| CD14 | +(1) | – | – | – | +(2) | + | + |
| CD172a | + | – or + (3) | ++/+ (4) | + | –/+ (5) | – or + (7) | + |
| CD205 | – | + | + | – | + | – | – |
| CD209 | – | + | + (6) | – | + | + | + |
| Flt3 | – | – | + | – | – | – | + |
| CD163 | – or + (7) | – or + (7, 8) | – | + | – or + (7, 8) | + | + |
| CX3CR1 | – | + or – (9) | + | – | + or – (9) | + | + |
| MerTK | – | – | – | + | – | + | + |
| CadM1 | – or + (7) | – or + (7) | – or + (7) | – or + (7) | – or + (7) | – or + (7) | – or + (7) |
(1) A minor subset is CD14 negative.
(2) Human MoDCs loose CD14 expression.
(3) Cattle and pigs have differential expression of CD172.
(4) Subpopulations of cells have differential expression of CD172.
(5) Conflicting data, this report and Vu Mahn et al. (43).
(6) Subset specific. Negative expression of CD209 in human DCs Granelli-Piperno et al. (58).
(7) Species-specific differences.
(8) Conflicting data, Park et al. (8) and Seo et al. (16).
(9) Conflicting information, this report and Maisonnasse et al. (31) and Fogg et al. (36).