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. 2019 Mar 29;10:255. doi: 10.3389/fphar.2019.00255

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Copyright © 2019 Song, Jiang, Wang, Xie, Liang, Sun, Gong, Liu and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JMT raised the IGF-1 expression in the serum and sciatic nerve of the DPN rats. (A) IGF-1 immunohistochemistry of cross section slices of sciatic nerve in Control, DM, JMT-L, JMT-M, JMT-H, and NTP groups, respectively. Immunohistochemical staining images were viewed at a magnification of 400. (B) Relative optical density of IGF-1 in different groups detected by immunohistochemistry. (C) Serum IGF-1 level in different groups measured by ELISA analysis. **P < 0.01 vs. Con group; ^▴P < 0.05 vs. DM group, ^▴▴P < 0.01 vs. DM group; ^▾P < 0.05 vs. JMT-M group; °P < 0.05 vs. NTP group.