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. 2019 Mar 29;10:176. doi: 10.3389/fpsyt.2019.00176

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Copyright © 2019 Li, Scuppa, Shen, Masi, Nasuti, Cannella and Ciccocioppo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Escalation of cocaine self-administration (CSA) in Wistar and msP rats. (A) The number of cocaine infusions that were received by Wistar rats in the first hour of ShA and LgA sessions was similar throughout training, with the exception of the first day. (B) The number of infusions that were received by Wistar rats during the entire 6 h LgA session increased over time. (C) The number of infusions that were received by msP rats during the first hour of the daily LgA sessions increased over training and was higher than ShA-trained msP rats beginning in the fifth session. (D) The number of infusions that were received by LgA-trained msP rats increased over training during the entire 6 h session. The data are expressed as mean ± SEM. ° p < 0.05, °° p < 0.01, °°°° p < 0.001, compared with ShA.