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. 2019 Mar 29;6:18. doi: 10.3389/fmolb.2019.00018

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Copyright © 2019 Dempsey, Bigotti, Adams and Brancaccio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LG-domains binding modes toward α-DG. Model of how different tandem assembly combinations might be required for fine modulation of α-DG binding affinity. The distance between the two disaccharide units that interact with two adjacent LG domains has not been determined, and the cartoon only depicts an example scenario. Because of their size, tandem LG domains cannot bind to adjacent GlcA-Xyl disaccharide units. A disaccharide unit is indicated, with Xyl: Xylose and GlucA: Glucuronic acid. The grouping on the right illustrates that LG domains that are able to bind α-DG as isolated units (in red) have not been found as neighbors. For color code, see Figure 9.