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. 2019 Mar 29;10:539. doi: 10.3389/fimmu.2019.00539

Figure 2.

Figure 2

miR-150 was highly expressed in B cells of the mantle zone of GCs in MG thymuses. Representative pictures of in situ hybridization of miR-150 in the cortex (A) and the medulla (B) of the thymus of a non-MG control and in the cortex (D), the medulla (E) and two different GCs (G,H) of the thymus of MG patients. miR-150 was located in B cells of the mantle zone of ectopic follicle with expanded GC (G,H). Scramble labeling was performed in the medulla (C) of the thymus of a non-MG control and in the cortex (F) and in the medulla/GC area (I) of the thymus of MG patients. 1-cm bar length represents 50 μm for 20X magnification and 25 μm for 40X magnification. All in situ hybridization experiments were done in formalin fixed paraffin embedded thymic tissue sections, as fully detailed in the method section.