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. 2019 Mar 29;10:634. doi: 10.3389/fimmu.2019.00634

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Copyright © 2019 Bracamonte-Baran, Chen, Hou, Talor, Choi, Davogustto, Taegtmeyer, Sung, Hackam, Nauen and Čiháková.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Undifferentiated naïve cardiac ILCs transiently express PLZF upon activation. (A) Timeline of PLZF⁺Ki67⁺ activation pattern under in vitro ILC2-differentiating conditions, IL-2+IL-7+IL-33. (B) Progression of GATA3 expression, showing the gate of GATA3⁺ ILCs. (C) Time course of ILC2 phenotype development, based on KLRG1 and ST2 co-expression. (D) Graph representing the evolution of the PLZF⁺Ki67⁺ co-expression. (E) Timeline of GATA3 expression during in vitro IL-33 stimulation. (F) Time curve showing the progression of ILC2 phenotype development. (G) Curve showing the evolution of IL-5 (blue) and IL-13 (red) production under IL-2+IL-7+IL-33 stimulation, as measured by ELISA of supernatants. Graphics show results of 1 of 2 independent experiments, each one made in triplicates for each condition. Asterisks represent the statistical significance of each time-point with respect to day 1-baseline values. Dots and whiskers show Mean and SD. Statistics calculated with one-way ANOVA and Bonferroni post-test. *P < 0.05; **P < 0.01; ***P < 0.001.