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. 2019 Mar 29;10:330. doi: 10.3389/fphys.2019.00330

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Copyright © 2019 Méndez-Ruette, Linsambarth, Moraga-Amaro, Quintana-Donoso, Méndez, Tamburini, Cornejo, Torres and Stehberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bicuculline microinfusion into the caudal sub-regions induces anxiolytic effects in the EPM. (A) Percentage of time spent in the open arms when vehicle (white bars, n = 6) or BMI (black bars, n = 8) was microinjected into pIC; (B) Percentage of time spent in the open arms when vehicle (white bars, n = 9) or BMI (black bars, n = 7) was microinjected into cIC. Total transitions during the EPM evaluation for the same rats microinjected into pIC (C) or cIC (D). Columns represent the mean ± SEM. ^∗p < 0.5.