Table 3.
The functional pathways of four MDS-specific genes with potential values in diagnosis and therapeutically targeting.
| Gene symbol | Gene name | Pathway |
|---|---|---|
| ABAT | 4-aminobutyrate aminotransferase | hsa00250: alanine, aspartate, and glutamate metabolism |
| hsa00280: valine, leucine, and isoleucine degradation | ||
| hsa00410: beta-alanine metabolism | ||
| hsa00640: propanoate metabolism | ||
| hsa00650: butanoate metabolism | ||
| FADD | Fas (TNFRSF6)-associated via death domain | hsa04210: apoptosis |
| hsa04620: toll-like receptor signaling pathway | ||
| hsa04622: RIG-I-like receptor signaling pathway | ||
| hsa05200: pathways in cancer | ||
| hsa05010: Alzheimer's disease | ||
| DAPP1 | Dual adaptor of phosphotyrosine and 3-phosphoinositides | hsa04662: B cell receptor signaling pathway |
| SMPD3 | Sphingomyelin phosphodiesterase 3 | hsa00600: sphingolipid metabolism |