OPUS Trial.

Trial name or title	Effectiveness of doxycycline for treating pleural effusions related to cancer in an outpatient population (OPUS)
Methods	RCT of doxycycline versus placebo administration via a PleurX catheter in MPE
Participants	Malignant pleural effusion; fully expanded lung post drainage of the pleural effusion Target recruitment of 50 participants
Interventions	Participants have a PleurX catheter inserted and are then randomised to intrapleural doxycycline or placebo
Outcomes	Primary: pleurodesis rate at 90 days Secondary: time to pleurodesis
Starting date	2009
Contact information	brepatenaude@toh.on.ca; kamjadi@toh.on.ca
Notes	NCT01411202