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. 2019 Mar 29;10:353. doi: 10.3389/fphys.2019.00353

FIGURE 5.

FIGURE 5

Effects of propafenone (2 μmol/L) on the channel gating properties. (A) Effect of propafenone on SSI in WT, propafenone shifted the V1/2 of SSI by -1.85 mV (from -63.41 ± 0.93 to -65.26 ± 2.61 mV, n = 7–10 cells for each group; P > 0.05). (B) Effect of propafenone on SSI in R1193Q, propafenone shifted the V1/2 by -6.96 mV (from -62.83 ± 1.72 to -69.79 ± 1.90 mV, n = 7–8 cells for each group, P < 0.05). (C) Effect of propafenone on time course of recovery from inactivation (protocol in inset), normalized current was plotted against a recovery interval (n = 8–10 cells for each group), time constants and relative weights on averaged data were as follows: for WT, Tfast = 12.0 ms, Afast = 0.71, Tslow = 53.1 ms, Aslow = 0.29; for R1193Q, Tfast = 21.2 ms, Afast = 0.70, Tslow = 123.5 ms, Aslow = 0.30.