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. 2019 Mar 29;2(3):e191286. doi: 10.1001/jamanetworkopen.2019.1286

Table 3. Causes of Mortality.

Cause of Mortality No. (%) P Value
DCC (n = 206) ICC (n = 478)
Respiratory 64 (31.1) 121 (25.3) .12
Severe RDS 14 (6.8) 12 (2.5) .007
PPHN 15 (7.3) 23 (4.8) .20
Pulmonary hemorrhage 13 (6.3) 27 (5.7) .74
Pulmonary hypoplasia 9 (4.4) 20 (4.2) .91
Severe BPD 7 (3.4) 25 (5.2) .30
Other 6 (2.9) 14 (2.9) .99
Late-onset sepsis 42 (20.4) 76 (15.9) .15
Gastrointestinal disorders 36 (17.5) 83 (17.4) .97
NEC stage ≥2 31 (15.1) 77 (16.1) .73
Spontaneous intestinal perforation 4 (1.9) 5 (1.1) .46
Other 1 (0.5) 1 (0.2) .51
Severe neurological injurya 22 (10.7) 93 (19.5) .005
Extreme prematurity 21 (10.2) 56 (11.7) .56
Refractory hypotension 5 (2.4) 8 (1.7) .55
Multiorgan failure 6 (2.9) 9 (1.9) .40
Other 10 (4.9) 32 (6.7) .36

Abbreviations: BPD, bronchopulmonary dysplasia; DCC, deferred cord clamping; ICC, immediate cord clamping; NEC, necrotizing enterocolitis; PPHN, persistent pulmonary hypertension of the newborn; RDS, respiratory distress syndrome.

a

Severe neurological injury includes intraventricular hemorrhage grade 3 and greater with or without persistent periventricular echogenicity.