Figure 1. Notch-3 Protein Model Highlighting Position of the Alzheimer Disease–Associated Single-Nucleotide Polymorphism rs149307620 (p.A284T).

Predicted model for wild-type allele with alanine at mutation site (A), mutant allele with threonine at mutation site (B), and binding of notch-3 (red) to JAG1 ligand (yellow) (C). Possible hydrogen bonding that would likely cause greater interaction with the ligand is displayed.