Table 2. Gene-Set Enrichment Analysis of NOTCH3/JAG1 Protein-Protein Interaction Network.
| PANTHER Pathway | No. of Genes Annotated to Pathway | No. of Genes in Network | Expected P Valuea | Fold Enrichment | Unadjusted P Value | FDR |
|---|---|---|---|---|---|---|
| Notch signaling | 42 | 22 | .06 | >100 | 3.98 × 10−51 | 6.48 × 10−49 |
| Presenilin | 123 | 14 | .18 | >100 | 7.09 × 10−28 | 5.78 × 10−26 |
| Amyloid secretase | 69 | 7 | .10 | >100 | 8.59 × 10−18 | 3.50 × 10−16 |
| Angiogenesis | 173 | 10 | .25 | 40.54 | 4.92 × 10−14 | 1.61 × 10−12 |
Abbreviations: FDR, false discovery rate; PANTHER, Protein Analysis Through Evolutionary Relationships classification system.
a
Expected probability of observing at least x number of genes out of the total number of genes in the PANTHER list annotated to a particular pathway, given the proportion of genes in the reference Homo sapiens whole genome that are annotated to that pathway.