Table 2. Payments by Treatment Group During 12 Monthsa .
| Payment Type and Month | Payment, $ (2015) | P Value | ||||
|---|---|---|---|---|---|---|
| TDD and CMM Group | CMM Only Group, Median (IQR) | Mean Difference (95% CI) | ||||
| Mean (SD) | Median (IQR) | Mean (SD) | ||||
| Inpatient hospital | ||||||
| 2 | 22 268 (51 667) | 3127 (20 638) | 47 747 (47 747) | 22 801 (41 828) | 25 479 (15 041 to 35 917) | <.001 |
| 6 | 42 436 (150 614) | 9899 (32 364) | 62 256 (100 759) | 33 176 (64 719) | 19 820 (−8912 to 48 552) | .18 |
| 12 | 45 741 (173 371) | 10 612 (36 160) | 94 845 (176 626) | 41 786 (88 586) | 49 104 (−1322 to 99 530) | .06 |
| Outpatient hospital | ||||||
| 2 | 22 073 (25 538) | 13 109 (31 449) | 11 943 (20 841) | 3841 (11 620) | 10 130 (6175 to 14 086) | <.001 |
| 6 | 35 978 (42 157) | 19 359 (39 798) | 33 005 (54 200) | 10 989 (30 329) | 2974 (−7788 to 13 745) | .59 |
| 12 | 40 417 (41 149) | 29 463 (36 545) | 48 596 (79 724) | 19 786 (35 796) | 8180 (−9896 to 26 256) | .37 |
| Office | ||||||
| 2 | 3031 (6444) | 880 (2085) | 4294 (9216) | 669 (3746) | 1263 (−86 to 2613) | .07 |
| 6 | 7840 (14 336) | 2889 (5799) | 11 490 (22 562) | 2545 (9445) | 3650 (−528 to 7828) | .09 |
| 12 | 14 319 (28 494) | 5679 (9418) | 21 098 (36 651) | 5498 (12 370) | 6780 (−2627 to 16 187) | .16 |
| Home | ||||||
| 2 | 1 041(1041) | 0 (531) | 1302 (1302) | 0 (700) | 261 (−691 to 1213) | .59 |
| 6 | 1450 (2993) | 0 (1577) | 2446 (8738) | 0 (1333) | 996 (−441 to 2432) | .17 |
| 12 | 1836 (1836) | 183 (1808) | 3864 (3864) | 306 (2188) | 2028 (−644 to 4699) | .14 |
| Emergency department | ||||||
| 2 | 470 (1909) | 0 (167) | 678 (1835) | 0 (597) | 208 (−110 to 525) | .20 |
| 6 | 1414 (6906) | 0 (735) | 1442 (3407) | 250 (1441) | 28 (−1199 to 1255) | .96 |
| 12 | 1391 (2898) | 0 (967) | 2189 (6383) | 311 (1441)) | 798 (−613 to 2209) | .27 |
| Outpatient pharmacy | ||||||
| 2 | 2926 (4671) | 970 (2828) | 2723 (4682) | 989 (2587) | 204 (−590 to 998) | .61 |
| 6 | 9278 (14 445) | 3969 (8594) | 8106 (13 390) | 3053 (6928) | 1172 (−1924 to 4267) | .46 |
| 12 | 18 039 (29 334) | 7563 (15 913) | 13 333 (21 472) | 6654 (12 176) | 4706 (−2752 to 12 164) | .21 |
| Other medical costs | ||||||
| 2 | 3544 (3544) | 0 (1121) | 1809 (1809) | 36 (1049) | 1735 (394 to 3076) | .01 |
| 6 | 3982 (9306) | 213 (2136) | 3210 (9547) | 124 (1990) | 772 (−1328 to 2871) | .47 |
| 12 | 4469 (8218) | 851 (2959) | 5784 (20 000) | 506 (3098) | 1315 (−3034 to 5664) | .55 |
| Total medical and pharmacy costs | ||||||
| 2 | 55 353 (58 610) | 39 097 (45 309) | 70 495 (75 307) | 48 757 (61 356) | 15 142 (3690 to 26 594) | .01 |
| 6 | 102 377 (164 124) | 65 876 (94 526) | 121 954 (122 492) | 93 226 (117 399) | 19 577 (−12 831 to 51 984) | .24 |
| 12 | 126 211 (187 581) | 80 491 (122 852) | 189 709 (218 735) | 136 620 (158 267) | 63 498 (4620 to 122 376) | .03 |
Abbreviations: CMM, conventional medical management; IQR, interquartile range; TDD, targeted drug delivery.
a
The TDD sample sizes were 268 at 2 months, 151 at 6 months, and 90 at 12 months. The CMM sample sizes were 268 at 2 months, 162 at 6 months, and 98 at 12 months.