Figure 3.

Model of the injectisome’s interaction with an eukaryotic host cell. Activation of the injectisome leads to secretion of the translocators that are deployed on the eukaryotic plasma membrane to form the translocon, which remains in contact with the needle to form a direct conduit between the bacterial and host cell cytosol that serves a passageway for the effector proteins (figure adapted from DOI: 10.7554/eLife.39514).