Skip to main content
. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: Neuron. 2019 Apr 3;102(1):75–90. doi: 10.1016/j.neuron.2019.03.013

Figure 2. Genome and transcriptome overlap between psychiatric disorders.

Figure 2.

(A) The psychiatric genomics consortium (PGC) reported common variant risk was significantly correlated for psychiatric illnesses, most notably attention hyperactivity disorder (ADHD), BD, MDD, and schizophrenia (Brainstorm Consortium, 2018). There was little or no overlap with neurological disorders, including Alzheimer’s disease, epilepsy, and migraine. Both psychiatric and neurological disease groups show correlations with neurocognitive quantitative phenotypes. Blue indicates positive, and red negative correlations; solid lines indicate higher degree of correlation. The first panel shows correlations between psychiatric conditions and with quantitative measures of neuroticism, smoking and education. The second panel shows correlations between psychiatric and neurological disorders. (B) A meta-analysis found significant overlap of transcriptome profiles between schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD) and major depressive disorder (MDD) (Gandal et al., 2018). There was no significant overlap with irritable bowel syndrome (IBD) and alcoholism (AAD).