Figure 5.

Microvascular platelet and leukocyte recruitment on intravital microscopy. Box-whisker plots for intravital microscopy data from the cremasteric microcirculation of vehicle (sham) or ponatinib-treated wild-type and ApoE^−/− mice illustrating the number of platelets adhering to the microvascular endothelium (A), the number of platelet strings or nets (B), the area of adherent platelet strings or nets (C), and the number of leukocytes adhered in postcapillary venules (D). *P < .05; **P < .01. (E-F) Histograms illustrating the distribution of leukocyte rolling velocities in cremasteric venules for ApoE^−/− mice on a WSD for animals treated with vehicle (E) or ponatinib (F). Rolling velocity was slower for ponatinib-treated mice (P < .01 by Mann-Whitney rank-sum test). ns, not significant.