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Vaccination and challenge scheme.
| Groups | Vaccine (D 0, 10, 20) | Route | Vaccine dose (μg HA) | adjuvant dose (μg) | injection volume (μl) | Challenge D 41 |
|---|---|---|---|---|---|---|
| 1 | PBS | i.m. | – | – | 50 | |
| 2 | WIV | i.m. | 0.5 | – | 50 | |
| 3 | WIV+ CAF01 | i.m. | 0.5 | 300 | 50 | |
| 4 | WIV | i.n. | 0.5 | – | 40 | |
| 5 | WIV+ CAF09 | i.n. | 0.5 | 300 | 40 | A/PR/8/34 |
| 6 | WIV+ CTA1-DD | i.n. | 0.5 | 5 | 40 | (H1N1)pdm09 |
| 7 | WIV+ CTA1-3M2e-DD | i.n. | 0.5 | 5 | 40 | X-31 |
