Table 1.
Type | Receptor | Alternative name/CD | Main function | Evidence after hRSV infection | Suggested role | References indicating a role during hRSV infection |
---|---|---|---|---|---|---|
Classical FcγRs (Recognize ICs on the cell surface) | FcγRI | CD64 | Activating | —a | — | — |
FcγRIIa | CD32a | Activating | — | — | — | |
FcγRIIb | CD32b | Inhibitory | — | — | — | |
FcγRIIc | CD32c | Activating | — | — | — | |
FcγRIIIa | CD16a | Activating | Increased presence of FcγRIIIA+ NK cells, and lung damage in patients with severe hRSV infections | The expression of FcγRIIIA on NK cells negatively influences the immune response during hRSV infection | Tripp et al., 2002 | |
FcγRIIIb | CD16b | Activating | — | — | — | |
Non-classical FcγRs (C-type lectins that recognize ICs on cell surface or non-classic FcγRs that recognize ICs inside the cell) | CD23 | CD23 | — | — | — | |
DC-SIGN | CD209 | Recognition of glycans through a carbohydrate recognition domain (CRD) | In vitro: mAb-blockade of DC-SIGN increases human DC maturation markers (CD80, CD86) after hRSV infection. | hRSV-DC interaction through DC-SIGN might impair DC maturation | Johnson et al., 2012 | |
FcRn | — | Control of endosomal routing | — | — | — | |
TRIM 21 | — | Elimination of ICs via recruitment of the proteasomal machinery | — | — | — |
No data are available.