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. 2019 Mar 29;10:350. doi: 10.3389/fphys.2019.00350

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Copyright © 2019 Tomek, Hao, Tomková, Lewis, Carr, Paterson, Rodriguez, Bub and Herring.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rapid pacing induces calcium alternans in sham and infarcted hearts. (A) Normalized calcium alternans magnitude of recordings in control condition against base cycle length for infarcted (n = 8) and sham hearts (n = 3). Asterisks represent statistical significance of the difference between sham and infarcted hearts at the level of 0.05 (^∗); assessed using Mann–Whitney U test. (B–D) Sample smoothed calcium traces illustrating the values of normalized alternans magnitude.