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. 2019 Mar 1;6(1):ENEURO.0242-18.2019. doi: 10.1523/ENEURO.0242-18.2019

Figure 5.

Figure 5.

FKBP51 overexpression modestly alters LTP induction and maintenance. Ex vivo hippocampal slices from rTgFKBP5 and littermate controls were prepared for LTP testing in the Schaffer collateral pathway. Following a 20-min baseline, slices were stimulated by one-train (A) or four-trains (B) of HFS at 100 Hz to induce LTP. Evoked fEPSPs ± SEM, normalized to baseline, were measured for 60 min following HFS. In the one-train protocol, slices from rTgFKBP5 (N = 5), WT (N = 6), and tTA (N = 5) mice were used. In the four-train protocol, rTgFKBP5 (N = 7), WT (N = 6), and tTA (N = 8) mice were used. Representative traces are shown: 1 (black) indicates baseline, 2 (teal) indicates initial early LTP potentiation in the first 3 min following potentiation, and 3 (gray) indicates late LTP in the last 3 min of recording. *p < 0.0001 by one-way ANOVA with Tukey’s Multiple Comparison’s test of the last 5 minutes. ***p < 0.0001 by two-way ANOVA.