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. 2019 Mar 31;26(1):443–458. doi: 10.1080/10717544.2019.1574935

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Cellular association of coated and noncoated PEIPOS with monolayers of three different cancer cell lines; (a) HeLa, (b) A2780-ADR, and (c) SKOV-3TR. Lipid concentration used for each cell line is indicated below each graph and incubation time was 4h. Control groups are nontreated cells. * indicates difference from control, whereas # indicates differences within the groups. Mean ± SD, n = 3, **p < .001, ****p < .0001. One-way ANOVA with Tukey’s multiple comparisons test. (d) Mode of internalization by A2780-ADR cells by flow cytometry. Lipid concentration was 100 µg/mL and incubation time was 90 min. PEGylated liposomes were modified with 3 mol% PEG2000-PE. Results are given as the fold-increase over the nonfluorescently labeled control formulations.