Table 1.
Physicochemical characteristics of noncoated and coated liposomes.
| Formulation | Mean diameter (nm) | PdI | Zeta potential (mV) | Concentration of PTX (µM) | Encapsulation efficiency (%) | Retained drug (%)a |
|---|---|---|---|---|---|---|
| 0% PEIPOS | 155 ± 9.2 | 0.08 ± 0.02 | −4.3 ± 1.5 | 132.3 ± 19.1 | 75.3 ± 11.2 | 74.7 ± 13.1 |
| 0.1% PEIPOS | 163 ± 4.8 | 0.12 ± 0.03 | +1.9 ± 0.2 | 151.3 ± 6.5 | 86.0 ± 4.0 | 94.0 ± 9.5 |
| 0.5% PEIPOS | 161 ± 9.4 | 0.08 ± 0.01 | +13.7 ± 2.3 | 147.7 ± 7.0 | 85.3 ± 3.2 | 97.7 ± 1.5 |
Results express the average of three independent batches prepared with 1.5% PTX (w/w)±SD.
a
Drug retained encapsulated in the liposomes was evaluated after storage of liposomes for seven days at 4 °C.