Figure 4. Graphical summary of hallmarks of cancer-related functions of PTEN presented on the CGC website.

(A) New gene summaries concisely integrate manually curated information on the impact of proteins (in this case PTEN)¹⁰⁸ coded by cancer genes on the hallmarks of cancer in simple graphical form. If the wild-type (WT) protein function promotes a process related to cancer, it is marked within the green outer ring. The protein suppressing a hallmark of cancer in its WT form is marked within the blue outer ring. [modified from Hanahan & Weinberg, Cell, 2011]¹⁵

(B) The alternative presentation of the summary of PTEN functions shows how an alteration resulting in gain- or loss-of-function of a gene may impact each of the hallmarks. As WT PTEN promotes (P) growth suppression, an inactivating PTEN mutation will lead to increased proliferation of mutant cells. (S = suppresses)