Scatter plot of fractional anisotropy by region-of-interest among MDD patients classified by long-term treatment outcome and healthy control subjects. Each data point represents one individual, and bars represent group mean±SD. Failure to achieve remission was associated with lower FA among MDD patients, statistically significant for the medial fornix. Bonferroni-adjusted post-hoc analyses revealed that, compared to control subjects, MDD non-remitters had 19.2% lower FA (p=0.009), whereas MDD partial-remitters and MDD full-remitters had numerically lower FA (12.5%, p=0.24 and 12.3%, p=0.13, respectively). See supplemental table 2 for more details on fractional anisotropy by region-of-interest and patient cohort. Abbreviations: HC, Healthy Control; MDD, Major depressive disorder; F-Rem, Full-remittters; P-Rem, Partial-remitters, N-Rem, Non-remitters. *F=4.28, df=3, 141, p=0.006.