Table 3.
Probabilistic Sensitivity Analysis Results. Financial and clinical impact of baseline strategy and three alternative risk reduction approaches, varying input parameters simultaneously. Unit costs are expressed per “effective” unit received by a hospital transfusion service from a blood collection agency. Annual costs assume 20,000 transfused units per year.
| Baseline | Pathogen Reduction | Point-of-Release Testing | Secondary Culture | |
|---|---|---|---|---|
| Unit Costs (US$): Mean (SD) | ||||
| Acquisition | 557.91 (0.14) | 748.95 (11.64) | 557.91 (0.14) | 557.91 (0.14) |
| Testing/Manipulation | 13.58 (0.01) | 0.00 (0.00) | 45.4 (3.71) | 30.83 (1.79) |
| Transfusion | 78.83 (4.40) | 78.83 (4.40) | 82.02 (1.79) | 78.80 (4.49) |
| Complications | 0.91 (2.09) | 0.00 (0.00) | 0.75 (1.89) | 0.61 (1.73) |
| Total | 651.23 (4.92) | 827.78 (12.38) | 686.23 (4.76) | 668.16 (5.09) |
| Unit Disposition (%) | ||||
| Uncontaminated Transfusion | 90.48% | 90.51% | 94.16% | 90.46% |
| Contaminated Transfusion | 0.04% | 0.00% | 0.02% | 0.01% |
| Disposed | 0.00% | 0.00% | 0.77% | 0.04% |
| Expired | 9.49% | 9.49% | 5.06% | 9.49% |
| Total Cost per Transfused Unit (US$): Mean (SD) | 719.48 (40.49) | 914.53 (52.79) | 728.65 (16.72) | 738.50 (42.43) |
| Annual Costs (Million US$): Mean (SD) | 14.39 (0.81) | 18.29 (1.06) | 14.57 (0.33) | 14.77 (0.85) |