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. Author manuscript; available in PMC: 2020 Apr 5.
Published in final edited form as: J Proteome Res. 2019 Jan 31;18(4):1513–1531. doi: 10.1021/acs.jproteome.8b00800

Figure 9.

Figure 9.

Pathway analysis of acetylated and succinylated mitochondrial proteins common to WT, SIRT3 KO and SIRT5 KO mice. (A) Pathway analysis of all WT, SIRT3 KO and SIRT5 KO mouse liver mitochondrial proteins with decreased succinylation. (B) Pathway analysis of all WT, SIRT3 KO and SIRT5 KO mouse liver mitochondrial proteins with increased acetylation. (C) Pathway analysis of all WT, SIRT3 KO and SIRT5 KO mouse liver mitochondrial proteins with increased acetylation and decreased succinylation at the same lysine residue as a function of chronic ethanol feeding (differential acyl switching proteins). (D) Pathway analysis of all WT, SIRT3 KO and SIRT5 KO mouse liver mitochondrial proteins with increased acetylation and/or decreased succinylation on different lysine residues as a function of chronic ethanol feeding.

* The first number after each bar on the graph represents the number of acetylated and/or succinylated proteins identified per pathway. The second number represents the fold enrichment for that pathway.