Table 1.

Patient demographics and disease characteristics, by IPAA surgical approach.

	Two-Stage IPAA (n=157)	Three-Stage IPAA (n=55)	P-value
Patient Demographics
Age (years), mean (SEM)	36.6 (1.0)	33.8 (1.8)	0.17
Female sex, N (%)	61 (39.6%)	26 (47.3%)	0.34
Race			0.79
White, N (%)	104 (88.9%)	25 (86.2%)
Hispanic, N (%)	7 (6.0%)	2 (6.9%)
Other, N (%)	6 (5.1%)	2 (6.9%)
Body mass index (kg/m2), mean (SEM)	25.1 (0.5)	24.3 (1.1)	0.43
Current smoker, N (%)	4 (3.0%)	2 (5.1%)	0.62
Age-adjusted CCI ≥1, N (%)	41 (30.4%)	10 (25.0%)	0.56
ASA ≥3, N (%)	17 (13.6%)	5 (13.5%)	1.00
History of prior abdominal surgery, N (%)	33 (24.6%)	8 (20.5%)	0.67
High-volume IBD surgeon, N (%)	140 (89.7%)	52 (94.6%)	0.41
Disease and Operative Characteristics
Steroid use at first operation, N (%)	100 (73.5%)	34 (87.2%)	0.09
Anti-TNF agent use at first operation, N (%)	42 (30.9%)	11 (28.2%)	0.85
Other immunomodulator use at first operation, N (%)	63 (46.3%)	9 (23.1%)	0.01
Indication for surgery			<0.001
Failure of medical management, N (%)	155 (98.7%)	40 (72.7%)
Perforation, N (%)	0 (0.0%)	7 (12.7%)
Toxic colitis, N (%)	1 (0.6%)	8 (14.6%)
Stricture, N (%)	1 (0.6%)	0 (0.0%)
Urgent procedure, N (%)	41 (30.2%)	33 (78.6%)	<0.001
Laparoscopic procedure, N (%)	34 (24.5%)	11 (26.8%)	0.84
Severe disease in specimen, N (%)	113 (83.1%)	33 (82.5%)	1.00
Severe disease at anastomosis, N (%)	74 (56.5%)	16 (42.1%)	0.14
Any disease at anastomosis, N (%)	122 (92.4%)	33 (86.8%)	0.33

IPAA: ileal pouch-anal anastomosis; SEM: standard error of the mean; CCI: Charlson-Comorbidity Index; ASA: American Society of Anesthesiologists; IBD: inflammatory bowel disease; TNF: tumor necrosis factor