Table 2.
Univariate analysis comparing perioperative and late outcomes after 2-stage versus 3-stage IPAA.
| Two-Stage IPAA (n=157) | Three-Stage IPAA (n=55) | P-value | |
|---|---|---|---|
| Perioperative Outcomes | |||
| Any perioperative complication after any stage, N (%) | 106 (67.5%) | 42 (76.4%) | 0.24 |
| Total perioperative complications after first operation per patient, mean (SEM) | 0.8 (0.1) | 0.6 (0.1) | 0.15 |
| Anastomotic leak, N (%) | 11 (8.1%) | 1 (2.6%) | 0.47 |
| Abdominal sepsis or abscess, N (%) | 25 (18.4%) | 7 (17.5%) | 1.00 |
| Other infections, N (%) | 15 (11.0%) | 4 (10.0%) | 1.00 |
| Thrombotic complications, N (%) | 8 (5.9%) | 3 (7.9%) | 0.71 |
| Ileus, N (%) | 42 (30.9%) | 8 (21.1%) | 0.31 |
| Any perioperative complication after first operation, N (%) | 93 (59.2%) | 30 (54.6%) | 0.63 |
| Total perioperative complications per patient, after all stages, mean (SEM) | 1.1 (0.1) | 1.3 (0.2) | 0.60 |
| Anastomotic leak, N (%) | 13 (9.6%) | 2 (5.0%) | 0.53 |
| Abdominal sepsis or abscess, N (%) | 27 (19.9%) | 10 (25.0%) | 0.51 |
| Other infections, N (%) | 36 (26.5%) | 16 (40.0%) | 0.12 |
| Thrombotic complications, N (%) | 8 (5.9%) | 3 (7.5%) | 0.71 |
| Ileus, N (%) | 55 (40.7%) | 18 (45.0%) | 0.72 |
| Postoperative length of stay | |||
| After IPAA, mean (SEM) | 6.6 (0.4) | 4.4 (0.3) | 0.003 |
| Total, mean (SEM) | 10.5 (0.6) | 13.0 (0.9) | 0.03 |
| Any readmission within 30 days of any operation, N (%) | 47 (34.6%) | 17 (42.5%) | 0.36 |
| Any readmission within 90 days of first operation, N (%) | 41 (27.7%) | 15 (27.8%) | 0.99 |
| Any readmission within 90 days of any operation, N (%) | 53 (35.8%) | 23 (42.6%) | 0.38 |
| Any reoperation within 90 days of first operation, N (%) | 8 (5.4%) | 3 (5.6%) | 0.97 |
| Any reoperation within 90 days of any operation, N (%) | 12 (8.1%) | 4 (7.4%) | 0.87 |
| Late Outcomes | |||
| Follow-up time (years), mean (SEM) | 5.1 (0.2) | 3.7 (0.4) | 0.01 |
| Pouchitis | 59 (47.6%) | 16 (40.0%) | 0.47 |
| Fistula or abscess | 14 (10.3%) | 6 (15.0%) | 0.40 |
| Small bowel obstruction | 25 (19.8%) | 2 (5.0%) | 0.03 |
| Incisional hernia | 5 (4.0%) | 1 (2.5%) | 1.00 |
| Anal stricture | 11 (8.8%) | 7 (17.5%) | 0.15 |
| Pouch failure | 9 (7.2%) | 1 (2.5%) | 0.45 |
| Total late complications per patient, mean (SEM) | 1.1 (0.1) | 1.0 (0.2) | 0.80 |
IPAA: ileal pouch-anal anastomosis; SEM: standard error of the mean