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. Author manuscript; available in PMC: 2020 Apr 4.
Published in final edited form as: Cell. 2019 Mar 28;177(2):315–325.e14. doi: 10.1016/j.cell.2019.02.036

Figure 3: 20E controls the egg-parasite correlation via its nuclear receptor.

Figure 3:

(A–B) Females injected with dsEcR (EcR) and fed on a P. falciparum infected blood meal (A) produce fewer eggs (Mann-Whitney) and (B) develop fewer oocysts at 7 d pIBM (GLM, Poisson distribution) compared to dsGFP-injected females (Cntrl). There is no effect on infection prevalence (P) (Chi-Squared). (C) The positive correlation between egg and oocyst numbers is lost in dsEcR-injected females (Spearman’s correlation). (D) dsEcR females have lower Vg expression at 24 h pBM compared to controls (means ± SEM, unpaired t-test, FDR corrected). NBF = non-blood fed. (E) The positive egg-oocyst correlation is also lost in dsUSP-injected females (USP) (Spearman’s correlation). N = sample size. Lines show data trends.