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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Pharmacol Ther. 2018 Nov 13;196:15–43. doi: 10.1016/j.pharmthera.2018.11.003

Figure 2. Trends of cardiovascular epigenetics.

Figure 2.

Yearly publication of epigenetic (A), cancer & epigenetic (B), cardiovascular disease & epigenetic (C). PubMed Search was performed on May 18, 2018 using the subject terms (epigenetic) for “epigenetic”; and (cancer AND epigenetic) for cancer epigenetics, and (cardiovascular disease AND epigenetic) for “cardiovascular disease”; Epigenetics (D) covers DNA and RNA methylation, histone modifications (acetylation, methylation, phosphorylation, etc.) and non-coding RNAs (micro-RNA and lncRNA-based mechanisms). These three broad categories of epigenetic modulation are distinct but are interrelated and coordinate to regulate gene expression.