Table 3.

Regions with statistically significant positive correlations between 5-HT_1A log(BP_F), where log indicates the natural logarithm, and GMV using voxel-wise regression in the MDD group (p < 0.05 FDR-corrected, k > 50)

MDD group, p < 0.05 FDR-corrected, k > 50
Voxels	Max	Max X (mm)	Max Y (mm)	Max Z (mm)	Cluster labels
1985	4.65	−41	11	−35	49% Temporal pole, 1% inferior temporal gyrus, anterior division
1254	4.69	−52	−16	−28	44% Inferior temporal gyrus, posterior division, 4% temporal fusiform cortex, anterior division, 4% inferior temporal gyrus, anterior division, 1% temporal fusiform cortex, posterior division
1180	5.05	38	−74	31	53% Lateral occipital cortex, superior division
1171	4.47	42	11	−37	60% Temporal pole
958	4.73	−6	−13	70	34% Precentral gyrus, 24% juxtapositional lobule cortex (formerly supplementary motor cortex), 1% superior frontal gyrus
923	5.40	−22	−44	65	38% Postcentral gyrus, 22% superior parietal lobule, 1% supramarginal gyrus, anterior division
751	5.42	5	−41	71	36% Postcentral gyrus, 28% precuneous cortex
673	5.69	47	−49	24	63% Angular gyrus, 8% supramarginal gyrus, posterior division
595	4.11	47	−5	54	71% Precentral gyrus, 5% postcentral gyrus, 1% middle frontal gyrus
467	5.32	44	−31	42	31% Supramarginal gyrus, anterior division, 18% postcentral gyrus, 5% supramarginal gyrus, posterior division, 1% superior parietal lobule
405	4.65	−38	−74	16.5	28% Lateral occipital cortex, superior division, 17% lateral occipital cortex, inferior division
357	4.44	−28	−60	60	33% Lateral occipital cortex, superior division, 20% superior parietal lobule
345	5.63	27.5	−55	7	18% Precuneous cortex, 15% lingual gyrus, 5% intracalcarine cortex
337	3.79	−44	−29	18	67% Parietal operculum cortex, 5% planum temporale, 5% Heschl’s gyrus (includes H1 and H2), 5% central opercular cortex, 1% superior temporal gyrus, posterior division
308	5.12	27	−76	−9	59% Occipital fusiform gyrus, 4% lingual gyrus, 3% lateral occipital cortex, inferior division
301	4.31	8	51	−24	52% Frontal pole, 20% frontal medial cortex
270	4.44	−33	−55	34	9% Lateral occipital cortex, superior division, 6% angular gyrus, 6% supramarginal gyrus, posterior division, 5% superior parietal lobule
228	4.64	−22	−13	57.5	15% Precentral gyrus, 12% superior frontal gyrus
225	3.84	−29	−78	−10	62% Occipital fusiform gyrus, 7% lateral occipital cortex, inferior division, 1% lingual gyrus
214	4.09	−12	−66	35	26% Precuneous cortex, 6% cuneal cortex, 1% lateral occipital cortex, superior division
210	5.03	−1.5	−53	5	3% Lingual gyrus, 2% precuneous cortex, 1% cingulate gyrus, posterior division, 1% intracalcarine cortex
204	4.95	−37.5	−5	62	42% Precentral gyrus, 18% middle frontal gyrus
189	4.92	24	26	38	23% Middle frontal gyrus, 9% superior frontal gyrus
161	3.44	−57	−17	32	55% Postcentral gyrus, 10% supramarginal gyrus, anterior division
139	4.28	12	−89	36	53% Occipital pole, 17% lateral occipital cortex, superior division, 2% cuneal cortex
133	3.65	−53	−39.5	52	35% Supramarginal gyrus, anterior division, 33% supramarginal gyrus, posterior division, 3% superior parietal lobule, 1% angular gyrus, 1% postcentral gyrus
123	4.67	22	−96	13.5	70% Occipital pole
113	3.74	−21	−37.5	7	Posterior hippocampus
111	3.77	39.5	−15	−40.5	22% Temporal fusiform cortex, posterior division, 7% inferior temporal gyrus, posterior division, 2% inferior temporal gyrus, anterior division, 1% temporal fusiform cortex, anterior division
110	4.79	32	−45	39	24% Superior parietal lobule, 9% supramarginal gyrus, posterior division, 4% angular gyrus
105	3.77	−18	−89.5	33	41% Occipital pole, 18% lateral occipital cortex, superior division, 1% cuneal cortex
92	4.87	−41	−47	−41	Cerebellum
82	3.91	−25	−87	11.5	20% Lateral occipital cortex, superior division, 7% occipital pole, 6% lateral occipital cortex, inferior division
65	4.33	−25.5	60	19	82% Frontal pole
61	3.57	28	5	−40.5	41% Temporal pole, 35% temporal fusiform cortex, anterior division, 4% parahippocampal gyrus, anterior division, 1% temporal fusiform cortex, posterior division, 1% inferior temporal gyrus, anterior division