Table 4.

Regions where correlations between voxel-wise 5-HT_1A log(BP_F), where log indicates the natural logarithm, and GMV are greater (HC > MDD) or smaller (HC < MDD) in the HC vs. MDD group, p < 0.001 uncorrected, k > 10)

Diagnosis by BPF interaction, p < 0.001 uncorrected, k > 10
Voxels	Max	Max X (mm)	Max Y (mm)	Max Z (mm)	Cluster labels
HC > MDD
15	3.48	35	−41	−6	10% Lingual gyrus, 7% temporal occipital fusiform cortex, 1% parahippocampal gyrus, posterior division
13	3.35	−19	−75	−15	33% Occipital fusiform gyrus, 20% lingual gyrus
HC < MDD
146	3.97	45	−9	57	52% Precentral gyrus, 13% postcentral gyrus
57	3.73	29	−58	5.5	12% Lingual gyrus, 7% intracalcarine cortex, 2% precuneous cortex
35	3.85	0	8	69	32% Juxtapositional lobule cortex (formerly supplementary motor cortex), 5% superior frontal gyrus
33	3.62	−9	−46	72	37% Postcentral gyrus, 13% superior parietal lobule, 12% precuneous cortex, 2% lateral occipital cortex, superior division, 1% precentral gyrus
19	3.63	−25	−43	72	31% Superior parietal lobule, 23% postcentral gyrus, 1% supramarginal gyrus, anterior division
15	3.34	−2	−9	73	18% Juxtapositional lobule cortex (formerly supplementary motor cortex), 8% precentral gyrus
13	3.90	−40	−50	−41	cerebellum
10	3.43	10	−41	78	62% Postcentral gyrus, 6% superior parietal lobule, 3% precuneous cortex, 2% precentral gyrus

This exploratory threshold was applied when no results survived the threshold of p < 0.05, k > 50 corrected for multiple comparisons using FDR. At this uncorrected threshold, clusters larger than 215 voxels were deemed significant at p < 0.05 corrected