Table 5.

Regions with positive or negative correlations (direction indicated by sign of T value) between raphe 5-HT_1A log(BP_F), where log indicates the natural logarithm, and voxel-wise GMV in HC (top table), MDD (middle table), and moderated by diagnosis (bottom table) at p < 0.001 uncorrected, k > 10)

Region	x	y	z	Voxels	T value
HC group, p value < 0.001 uncorrected, k > 10
Cerebellum	−13	−76	−29	547	4
25% Inferior frontal gyrus, pars opercularis, 6% inferior frontal gyrus, pars triangularis, 5% middle frontal gyrus, 4% precentral gyrus	44	20	22	133	3.98
38% Supramarginal gyrus, posterior division, 8% angular gyrus, 3% parietal operculum cortex, 2% supramarginal gyrus, anterior division, 1% planum temporale	−54	−45	34	103	3.88
Cerebellum	−2	−45	−10	88	3.67
38% Lingual gyrus, 22% occipital fusiform gyrus, 8% occipital pole, 1% lateral occipital cortex, inferior division	10	−85.5	−9	39	3.61
63% subcallosal cortex, 4% frontal orbital cortex	−8	12	−19.5	371	−3.94
48% Precuneous cortex, 30% cingulate gyrus, posterior division	−7	−54	32	228	−2.75
34% Lateral occipital cortex, superior division, 8% precuneous cortex, 2% cuneal cortex	18	−66	48	37	−2.74
26% Temporal pole, 25% parahippocampal gyrus, anterior division, 5% temporal fusiform cortex, anterior division, 1% inferior temporal gyrus, anterior division	19	5	−40	33	−2.69
MDD group, p value < 0.001 uncorrected, k > 10
28% Central opercular cortex, 27% postcentral gyrus, 4% supramarginal gyrus, anterior division, 3% parietal operculum cortex, 2% precentral gyrus, 1% planum temporale	61	−12.5	19	168	4.2
48% Postcentral gyrus, 25% central opercular cortex, 2% parietal operculum cortex, 2% precentral gyrus, 1% planum temporale	−62	−13	16	24	3.44
55% Lateral occipital cortex, inferior division, 14% occipital fusiform gyrus	43	−71	−14	420	−3.6
47% Middle frontal gyrus, 3% inferior frontal gyrus, pars triangularis, 1% inferior frontal gyrus, pars opercularis	−45	24.5	33	418	−3.55
17% Inferior frontal gyrus, pars triangularis, 10% frontal pole, 3% middle frontal gyrus	44	33	10	413	−3.55
25% Middle frontal gyrus, 14% precentral gyrus	−37	5	44	219	−3.26
23% Middle temporal gyrus, posterior division, 20% middle temporal gyrus, temporo-occipital part, 3% inferior temporal gyrus, temporo-occipital part, 3% inferior temporal gyrus, posterior division	60	−38	−9	115	−3.28
28% Planum temporale, 13% superior temporal gyrus, posterior division, 8% supramarginal gyrus, posterior division, 4% parietal operculum cortex, 1% angular gyrus, 1% middle temporal gyrus, posterior division	60	−33	17	109	−3.08
52% Middle frontal gyrus	44.5	25	38	105	−2.81
31% Supramarginal gyrus, posterior division, 11% angular gyrus, 3% parietal operculum cortex	−50	−48	36.5	75	−2.85
27% Angular gyrus, 17% lateral occipital cortex, superior division, 5% supramarginal gyrus, posterior division, 5% superior parietal lobule	−37	−57	39	70	−3.08
40% Postcentral gyrus, 20% precentral gyrus	37	−21	46	69	−2.7
41% Postcentral gyrus, 25% precentral gyrus	36	−24	60	62	−2.56
8% Frontal pole, 2% inferior frontal gyrus, pars triangularis, 1% frontal orbital cortex	−37	41	2	57	−2.89
31% Cingulate gyrus, anterior division, 29% paracingulate gyrus	−11	34.5	21	40	−2.78
47% Middle frontal gyrus	32	24	43	30	−2.86
42% Precuneous cortex, 18% cuneal cortex, 11% supracalcarine cortex, 1% intracalcarine cortex	−16.5	−67	24	26	−2.53
34% Middle temporal gyrus, temporo-occipital part, 6% inferior temporal gyrus, temporo-occipital part, 2% middle temporal gyrus, posterior division, 1% inferior temporal gyrus, posterior division	−54	−48	−6	18	−2.67
52% Temporal occipital fusiform cortex, 16% occipital fusiform gyrus, 1% inferior temporal gyrus, temporo-occipital part	36	−58	−14	15	−2.56
Diagnosis by BPF, p value < 0.001 uncorrected, k > 10
HC > MDD
Cerebellum	−11	−77	−27.5	393	4.07
38% Supramarginal gyrus, posterior division, 10% angular gyrus, 3% parietal operculum cortex, 1% planum temporale	−53	−47	34	241	4.42
22% Inferior frontal gyrus, pars opercularis, 5% inferior frontal gyrus, pars triangularis, 3% precentral gyrus, 1% middle frontal gyrus	45	20	22	95	3.9
23% Middle frontal gyrus, 23% frontal pole, 19% inferior frontal gyrus, pars triangularis	41	35	16	36	3.49
51% Middle frontal gyrus, 2% inferior frontal gyrus, pars opercularis	−46	19	39	34	3.71
20% Middle frontal gyrus, 2% superior frontal gyrus	−32	18	43	15	3.28
23% Frontal pole, 21% inferior frontal gyrus, pars triangularis, 6% frontal orbital cortex, 1% frontal operculum cortex	44	36	2	12	3.45
53% Lateral occipital cortex, inferior division, 5% occipital fusiform gyrus	40.5	−70	−5.45	11	3.39

This exploratory threshold was applied when no results survived the threshold of p < 0.05, k > 50 corrected for multiple comparisons using FDR. At this uncorrected threshold, clusters larger than 215 voxels were deemed significant at p < 0.05 corrected