Table 2.

Two-stage hyperinsulinaemic–euglycaemic clamp assessment of insulin sensitivity in BAM and WEM with type 2 diabetes

Measurement	Basal				Hyperinsulinaemic–euglycaemic clamp
	BAM n = 15	WEM n = 12	Mean difference or ratio of the geometric mean (95% CI) (BAM − WEM) (95% CI)	p	BAM n = 18	WEM n = 15	Mean difference (BAM − WEM) (95% CI)	p
Glucose disposal rate (M; mg kg−1 min−1)	–	–	–	–	4.52 (2.07)	4.00 (1.70)	0.52 (−0.82, 1.89)	0.44
Peripheral glucose utilisation (Rd; μmol kg−1 min−1)	–	–	–	–	26.8 (10.4)	24.2 (8.5)	2.60 (−4.22, 9.41)	0.44
Endogenous glucose production (Ra; μmol kg−1 min−1)	8.82 (1.49)	9.25 (1.66)	−0.43 (−1.69, 0.81)	0.48	5.76 (1.73)	6.50 (2.34)	−0.74 (−2.18, 0.71)	0.31
Lipolysis (glycerol Ra; μmol kg−1 min−1)	1.51 (1.31, 1.75)	1.82 (1.55, 2.15)	0.83 (0.67, 1.02)	0.08	1.06 (0.47)	1.18 (0.33)a	−0.12 (−0.43, 0.19)	0.43

Data expressed as mean (SD) for normally distributed data and geometric mean (95% CI) for skewed data

M values and glucose R_d assessments were derived from the high-dose insulin infusion (40 mU m⁻² BSA min⁻¹), glucose and glycerol R_a assessments were derived from the low-dose insulin infusion (10 mU m⁻² BSA min⁻¹) of the hyperinsulinaemic–euglycaemic clamp and at baseline

^aWEM sample size = 13

p values were generated using an independent sample Student’s t test to compare BAM and WEM